Dissolution Requirements For Active Drugs In Medicinal Capsules

The manufacture of medicinal hard and soft capsules is a complex process that requires precise calculations

    The manufacture of medicinal hard and soft capsules is a complex process that requires precise calculations. Once the capsules are manufactured, their properties may also vary. Let's take a look at some of the key technical considerations for hard and soft capsules.

    Active Pharmaceutical Ingredient (API) / Dissolution is the rate at which the capsule dissolves in the stomach, allowing the active ingredient to be absorbed by the body. Gelatin, for example, has one of the best, if not the best, dissolution rates of an API, allowing rapid absorption of the API by the body. This is one of the most important considerations for drugmakers.

    Oxygen permeability

    Some APIs have complex properties that make them sensitive to oxidation. For these formulations, capsules are the best option because they provide the best protection. Because of its low oxygen permeability, gelatin is the best excipient when handling oxygen-sensitive APIs. The alternative HPMC has a high potential for oxygen permeability, which means that other ingredients (such as antioxidants) must be used, which adds to the overall cost. Therefore, whenever possible, manufacturers will always choose gelatin capsules when oxygen sensitivity is considered.

    Water permeability

Another consideration is moisture penetration. Depending on the capsule type, steam has different effects. HPMC has a lower water content than gelatin. However, the jury is still out on whether HPMC actually performs better than gelatin in terms of water permeability.

    Xinchang Hexin Capsule Co., Ltd. is China's Clear Vegetarian Capsules Supplier and Capsule Supplier, producing and selling Empty HPMC Capsules, and Empty Gelatin Capsules.


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